Article
p75NTR ectodomain is a physiological neuroprotective molecule against amyloid-beta toxicity in the brain of Alzheimer's disease.
Molecular psychiatry - 1 Nov 2015
Yao X-Q, Jiao S-S, Saadipour K, Zeng F, Wang Q-H, Zhu C, Shen L-L, Zeng G-H, Liang C-R, Wang J, Liu Y-H, Hou H-Y, Xu X, Su Y-P, Fan X-T, Xiao H-L, Lue L-F, Zeng Y-Q, Giunta B, Zhong J-H, Walker D G, Zhou H-D, Tan J, Zhou X-F, Wang Y-J
Abstract excerpt
In Alzheimer's disease (AD), neurodegenerative signals such as amyloid-beta (Aβ) and the precursors of neurotrophins, outbalance neurotrophic signals, causing synaptic dysfunction and neurodegeneration. The neurotrophin receptor p75 (p75NTR) is a receptor of Aβ and mediates Aβ-induced neurodegenerative signals. The shedding of its ectodomain from the cell surface is physiologically regulated; however, the...
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