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Article

Emerging roles of N- and C-terminally truncated Aβ species in Alzheimer’s disease

2 Dec 2019

Abstract excerpt

Introduction: Alzheimer’s disease (AD) is characterized by a cerebral accumulation and aggregation of amyloid-β (Aβ) peptides, which mainly accumulate in the form of extracellular deposits. In addition to the well-described full-length peptides Aβ1-40 and Aβ1-42, a variety of amino- and carboxy-terminally truncated Aβ variants have been identified in brain samples from sporadic and familial AD cases.Areas...

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PMID: 31814468
DOI: 10.1080/14728222.2019.1702972

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