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Article

The p75 neurotrophin receptor promotes amyloid-beta(1-42)-induced neuritic dystrophy in vitro and in vivo.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 26 Aug 2009

Knowles Juliet K, Rajadas Jayakumar, Nguyen Thuy-Vi V, Yang Tao, LeMieux Melburne C, Vander Griend Lilith, Ishikawa Chihiro, Massa Stephen M, Wyss-Coray Tony, Longo Frank M

Abstract excerpt

Oligomeric forms of amyloid-beta (Abeta) are thought to play a causal role in Alzheimer's disease (AD), and the p75 neurotrophin receptor (p75(NTR)) has been implicated in Abeta-induced neurodegeneration. To further define the functions of p75(NTR) in AD, we examined the interaction of oligomeric Abeta(1-42) with p75(NTR), and the effects of that interaction on neurite integrity in neuron cultures and in a...

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Identifiers

PMID: 19710315
DOI: 10.1523/JNEUROSCI.0620-09.2009
PMCID: PMC2771439

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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