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Article

proBDNF Accelerates Brain Amyloid-β Deposition and Learning and Memory Impairment in APPswePS1dE9 Transgenic Mice.

Journal of Alzheimer's disease : JAD - 1 Jan 2017

Chen Jia, Zhang Tao, Jiao Shusheng, Zhou Xinfu, Zhong Jinhua, Wang Yanjiang, Liu Juan, Deng Juan, Wang Shuiping, Xu Zhiqiang

Abstract excerpt

BACKGROUND: Alzheimer's disease (AD) is pathologically known for the amyloid-β (Aβ) deposition, neurofibrillary tangles, and neuronal loss in the brain. The precursor of brain-derived neurotrophic factor (proBDNF) before proteolysis has opposing functions to its mature form in neuronal survival and neurite growth. However, the role of proBDNF in the pathogenesis of AD remains unclear. OBJECTIVE: To investigate...

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Identifiers

PMID: 28697556
DOI: 10.3233/JAD-161191

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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