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Amelioration of symptomatic Alzheimer’s Disease after selective impairment of p75 <sup>NTR</sup> function in adult forebrain excitatory neurons

2025-10-09

Abstract excerpt

The p75 neurotrophin receptor (p75 NTR ) contributes to the development of Alzheimer’s Disease (AD) pathology by enhancing amyloid precursor protein (APP) cleavage and amyloid plaque formation. However, the cell type-specific and temporal roles of p75 NTR in AD progression remain unclear. Here, we report that conditional knock-in of functionally impaired p75 NTR variants lacking the death domain (ΔDD) or transm...

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Literature Corpus work
417a9625-dd8d-53ac-9f60-0c4aa02f56d6
DOI
10.1101/2025.10.08.681148
Open publication

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Amelioration of symptomatic Alzheimer’s Disease after selective impairment of p75 <sup>NTR</sup> function in adult forebrain excitatory neuronsDOI 10.1101/2025.10.08.681148
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