Article
p75NTR regulates Abeta deposition by increasing Abeta production but inhibiting Abeta aggregation with its extracellular domain.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 9 Feb 2011
Wang Yan-Jiang, Wang Xin, Lu Jian-Jun, Li Qiao-Xin, Gao Chang-Yue, Liu Xiao-Hong, Sun Yin, Yang Miao, Lim Yoon, Evin Genevieve, Zhong Jin-Hua, Masters Colin, Zhou Xin-Fu
Abstract excerpt
Accumulation of toxic amyloid-β (Aβ) in the cerebral cortex and hippocampus is a major pathological feature of Alzheimer's disease (AD). The neurotrophin receptor p75NTR has been proposed to mediate Aβ-induced neurotoxicity; however, its role in the development of AD remains to be clarified. The p75NTR/ExonIII-/- mice and APPSwe/PS1dE9 mice were crossed to generate transgenic AD mice with deletion of p75NTR gene....
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