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Article

A neuroprotective brain-penetrating endopeptidase fusion protein ameliorates Alzheimer disease pathology and restores neurogenesis.

The Journal of biological chemistry - 20 Jun 2014

Spencer Brian, Verma Inder, Desplats Paula, Morvinski Dinorah, Rockenstein Ed, Adame Anthony, Masliah Eliezer

Abstract excerpt

Alzheimer disease (AD) is characterized by widespread neurodegeneration throughout the association cortex and limbic system, deposition of amyloid-β peptide (Aβ) in the neuropil and around the blood vessels, and formation of neurofibrillary tangles. The endopeptidase neprilysin has been successfully used to reduce the accumulation of Aβ following intracranial viral vector delivery or ex vivo manipulated...

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Identifiers

PMID: 24825898
DOI: 10.1074/jbc.M114.557439
PMCID: PMC4067222

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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