Article

The Nerve Growth Factor Receptor (NGFR/P75<sup>ntr</sup>): A Major Player in Alzheimer’s Disease

2023-01-13

Abstract excerpt

Alzheimer’s disease (AD) represents the most prevalent type of dementia in elderly people, primarily characterized by brain accumulation of beta-amyloid (Aβ) peptides, derived from Amyloid Precursor Protein (APP), in the extracellular space (amyloid plaques) and intracellular deposits of the hyperphosphorylated form of the protein tau (p-tau; tangles or neurofibrillary aggregates). The Nerve growth fact...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7a1db031-e309-58af-bc18-ac9a20fc599c
DOI: 10.20944/preprints202301.0239.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Nerve Growth Factor Receptor (NGFR/P75<sup>ntr</sup>): A Major Player in Alzheimer’s DiseaseDOI 10.20944/preprints202301.0239.v1Read

Association of rs2072446 in the NGFR gene with the risk of Alzheimer's disease and amyloid-β deposition in the brain.Semantic proximity Read

?-amyloid binds to p75NTRand activates NF?B in human neuroblastoma cellsSemantic proximity Read

p75 Neurotrophin Receptor Shapes the Dynamics of Adult Hippocampal Neurogenesis in Alzheimer's DiseaseSemantic proximity Read

p75 Neurotrophin Receptor Shapes the Dynamics of Adult Hippocampal Neurogenesis in Alzheimer’s DiseaseSemantic proximity Read

Development of a non invasive NGF-based therapy for Alzheimer's disease.Semantic proximity Read

Amelioration of symptomatic Alzheimer’s Disease after selective impairment of p75 <sup>NTR</sup> function in adult forebrain excitatory neuronsSemantic proximity Read

Neurotrophins and neurodegenerationSemantic proximity Read

p75 reduces beta-amyloid-induced sympathetic innervation deficits in an Alzheimer's disease mouse model.Semantic proximity Read

p75 neurotrophin receptor signaling through the RhoA/ROCK pathway contributes to Alzheimer’s Disease tauopathySemantic proximity Read

Genetic polymorphisms of nerve growth factor receptor (NGFR) and the risk of Alzheimer's disease.Semantic proximity Read

p75NTR regulates Abeta deposition by increasing Abeta production but inhibiting Abeta aggregation with its extracellular domain.Semantic proximity Read

ProNGF\NGF imbalance triggers learning and memory deficits, neurodegeneration and spontaneous epileptic-like discharges in transgenic mice.Semantic proximity Read