Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Intramuscular delivery of p75NTR ectodomain by an AAV vector attenuates cognitive deficits and Alzheimer's disease-like pathologies in APP/PS1 transgenic mice.

Journal of neurochemistry - 1 Jul 2016

Wang Qing-Hua, Wang Ye-Ran, Zhang Tao, Jiao Shu-Sheng, Liu Yu-Hui, Zeng Fan, Li Jing, Yao Xiu-Qing, Zhou Hua-Dong, Zhou Xin-Fu, Wang Yan-Jiang

Abstract excerpt

The neurotrophin receptor p75 (p75NTR) is a receptor for amyloid-beta (Aβ) and mediates Aβ-induced neurodegenerative signals. The ectodomain of p75NTR (p75ECD) is a physiological protective factor against Aβ in Alzheimer's disease (AD). We have previously demonstrated that the shedding of p75ECD from the cell surface is down-regulated in AD brains and restoration of the p75ECD level in the brain, through...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid beta-Protein Precursor
Share to Cognition Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dependovirus

Share to Injections, Intramuscular

Share to Maze Learning

Share to Presenilin-1

Share to Receptor, Nerve Growth Factor

Share to Transduction, Genetic

Source

Identifiers

PMID: 26991827
DOI: 10.1111/jnc.13616

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Intramuscular delivery of p75NTR ectodomain by an AAV vector attenuates cognitive deficits and Alzheimer's disease-like pathologies in APP/PS1 transgenic mice.PMID 26991827Read ↗

p75NTR ectodomain is a physiological neuroprotective molecule against amyloid-beta toxicity in the brain of Alzheimer's disease.Semantic proximity Read ↗

Amelioration of symptomatic Alzheimer’s Disease after selective impairment of p75 <sup>NTR</sup> function in adult forebrain excitatory neuronsSemantic proximity Read ↗

Expression of amyloid-β antibody via AAV of CNS tropism alleviates Alzheimer’s disease in miceSemantic proximity Read ↗

Virus-Mediated Gene Transfer of Soluble Amyloid Precursor Protein-alpha via Systemic Injection in a Mouse Model of Alzheimer's DiseaseSemantic proximity Read ↗

p75NTR regulates Abeta deposition by increasing Abeta production but inhibiting Abeta aggregation with its extracellular domain.Semantic proximity Read ↗

Global brain delivery of neprilysin gene by intravascular administration of AAV vector in miceSemantic proximity Read ↗

Enhanced delivery of low-dose of aducanumab via FUS in 5xFAD mice, an AD modelSemantic proximity Read ↗

p75 reduces beta-amyloid-induced sympathetic innervation deficits in an Alzheimer's disease mouse model.Semantic proximity Read ↗

AAV-mediated progranulin delivery to a mouse model of progranulin deficiency causes T cell-mediated hippocampal degenerationSemantic proximity Read ↗

Induction of tauopathy in a mouse model of amyloidosis using intravenous administration of adeno‐associated virus vectors expressing human P301L tauSemantic proximity Read ↗

Intracerebral adeno-associated virus gene delivery of apolipoprotein E2 markedly reduces brain amyloid pathology in Alzheimer's disease mouse models.Semantic proximity Read ↗

A neuroprotective brain-penetrating endopeptidase fusion protein ameliorates Alzheimer disease pathology and restores neurogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.