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Inactive variants of death receptor p75 <sup>NTR</sup> reduce Alzheimer’s neuropathology by interfering with APP internalization

2020-01-10

Abstract excerpt

A prevalent model of Alzheimer’s disease (AD) pathogenesis postulates the generation of neurotoxic fragments derived from the amyloid precursor protein (APP) after its internalization to endocytic compartments. However, the molecular pathways that regulate APP internalization and intracellular trafficking in neurons are unknown. Here we report that 5xFAD mice, an animal model of AD, expressing signaling-deficient...

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Literature Corpus work
be6a794e-32d2-58e4-a7e3-62dbcd2b9f3a
DOI
10.1101/2020.01.10.901926
Open publication

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Inactive variants of death receptor p75 <sup>NTR</sup> reduce Alzheimer’s neuropathology by interfering with APP internalizationDOI 10.1101/2020.01.10.901926
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