Article
Low TGFβ1 expression prevents and high expression exacerbates diabetic nephropathy in mice.
Proceedings of the National Academy of Sciences of the United States of America - 5 May 2015
Hathaway Catherine K, Gasim Adil M H, Grant Ruriko, Chang Albert S, Kim Hyung-Suk, Madden Victoria J, Bagnell C Robert, Jennette J Charles, Smithies Oliver, Kakoki Masao
Abstract excerpt
Nephropathy develops in many but not all patients with long-standing type 1 diabetes. Substantial efforts to identify genotypic differences explaining this differential susceptibility have been made, with limited success. Here, we show that the expression of the transforming growth factor β1 gene (Tgfb1) affects the development of diabetic nephropathy in mice. To do this we genetically varied Tgfb1 expression in...
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