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Article

High Elmo1 expression aggravates and low Elmo1 expression prevents diabetic nephropathy.

Proceedings of the National Academy of Sciences of the United States of America - 23 Feb 2016

Hathaway Catherine K, Chang Albert S, Grant Ruriko, Kim Hyung-Suk, Madden Victoria J, Bagnell C Robert, Jennette J Charles, Smithies Oliver, Kakoki Masao

Abstract excerpt

Human genome-wide association studies have demonstrated that polymorphisms in the engulfment and cell motility protein 1 gene (ELMO1) are strongly associated with susceptibility to diabetic nephropathy. However, proof of causation is lacking. To test whether modest changes in its expression alter the severity of the renal phenotype in diabetic mice, we have generated mice that are type 1 diabetic because they...

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Source

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Identifiers

PMID: 26858454
DOI: 10.1073/pnas.1600511113
PMCID: PMC4776516

Genes

ELMO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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High Elmo1 expression aggravates and low Elmo1 expression prevents diabetic nephropathy.PMID 26858454Read ↗

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Confirmation of genetic associations at ELMO1 in the GoKinD collection supports its role as a susceptibility gene in diabetic nephropathy.Semantic proximity Read ↗

Association of Genetic Variants of ELMO1 Gene With Diabetic Nephropathy in the North Indian PopulationSemantic proximity Read ↗

Association of ELMO1 gene polymorphisms with diabetic nephropathy in Chinese population.Semantic proximity Read ↗

ELMO1 variants and susceptibility to diabetic nephropathy in American Indians.Semantic proximity Read ↗

Association between ELMO1 gene polymorphisms and diabetic nephropathy in an Iranian populationSemantic proximity Read ↗

ELMO1 dependent efferocytosis protects from nephrotoxin induced acute kidney injurySemantic proximity Read ↗

Glomerular Endothelial Mitochondrial Dysfunction Is Essential and Characteristic of Diabetic Kidney Disease SusceptibilitySemantic proximity Read ↗

Variants in intron 13 of the ELMO1 gene are associated with diabetic nephropathy in African Americans.Semantic proximity Read ↗

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