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Article

Allelic Depletion of <i>grem1</i> Attenuates Diabetic Kidney Disease

28 Apr 2009

Abstract excerpt

OBJECTIVE: Gremlin (grem1) is an antagonist of the bone morphogenetic protein family that plays a key role in limb bud development and kidney formation. There is a growing appreciation that altered grem1 expression may regulate the homeostatic constraints on damage responses in diseases such as diabetic nephropathy. RESEARCH DESIGN AND METHODS: Here we explored whether knockout mice heterozygous for grem1 gene...

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PMID: 19401426
DOI: 10.2337/db08-1365

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