Article
Assessment of diabetic nephropathy in the Akita mouse.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2012
Chang Jae-Hyung, Gurley Susan B
Abstract excerpt
Akita mice have type 1 diabetes mellitus caused by a spontaneous point mutation in the Ins2 gene which leads to misfolding of insulin, resulting in pancreatic β-cell failure. Akita mice develop pronounced and sustained hyperglycemia, high levels of albuminuria, and consistent histopathological changes, suggesting that these mice may be suitable as an experimental platform for modeling diabetic nephropathy. One...
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