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Article

TGF-alpha mediates genetic susceptibility to chronic kidney disease.

Journal of the American Society of Nephrology : JASN - 1 Feb 2011

Laouari Denise, Burtin Martine, Phelep Aurélie, Martino Carla, Pillebout Evangeline, Montagutelli Xavier, Friedlander Gérard, Terzi Fabiola

Abstract excerpt

The mechanisms of progression of chronic kidney disease (CKD) are poorly understood. Epidemiologic studies suggest a strong genetic component, but the genes that contribute to the onset and progression of CKD are largely unknown. Here, we applied an experimental model of CKD (75% excision of total renal mass) to six different strains of mice and found that only the FVB/N strain developed renal lesions. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21183591
DOI: 10.1681/ASN.2010040356
PMCID: PMC3029905

Genes

EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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