Article
Lack of both bradykinin B1 and B2 receptors enhances nephropathy, neuropathy, and bone mineral loss in Akita diabetic mice.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jun 2010
Kakoki Masao, Sullivan Kelli A, Backus Carey, Hayes John M, Oh Sang Su, Hua Kunjie, Gasim Adil M H, Tomita Hirofumi, Grant Ruriko, Nossov Sarah B, Kim Hyung-Suk, Jennette J Charles, Feldman Eva L, Smithies Oliver
Abstract excerpt
An insertion polymorphism of the angiotensin-I converting enzyme gene (ACE) is common in humans and the higher expressing allele is associated with an increased risk of diabetic complications. The ACE polymorphism does not significantly affect blood pressure or angiotensin II levels, suggesting that the kallikrein-kinin system partly mediates the effects of the polymorphism. We have therefore explored the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.