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Article

Diabetic kidney lesions of GIPRdn transgenic mice: podocyte hypertrophy and thickening of the GBM precede glomerular hypertrophy and glomerulosclerosis.

American journal of physiology. Renal physiology - 1 Apr 2009

Herbach Nadja, Schairer Irene, Blutke Andreas, Kautz Sabine, Siebert Angela, Göke Burkhard, Wolf Eckhard, Wanke Ruediger

Abstract excerpt

Diabetic nephropathy is the leading cause of end-stage renal disease and the largest contributor to the total cost of diabetes care. Rodent models are excellent tools to gain more insight into the pathogenesis of diabetic nephropathy. In the present study, we characterize the age-related sequence of diabetes-associated kidney lesions in GIPR(dn) transgenic mice, a novel mouse model of early-onset diabetes...

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Source

Identifiers

PMID: 19211686
DOI: 10.1152/ajprenal.90665.2008

Genes

GIPR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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