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Article

Impact of genetic background on nephropathy in diabetic mice

23 Aug 2005

Abstract excerpt

With the goal of identifying optimal platforms for developing better models of diabetic nephropathy in mice, we compared renal effects of streptozotocin (STZ)-induced diabetes among five common inbred mouse strains (C57BL/6, MRL/Mp, BALB/c, DBA/2, and 129/SvEv). We also evaluated the renal consequences of chemical and genetic diabetes on the same genetic background (C57BL/6). There was a hierarchical response of...

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PMID: 16118394
DOI: 10.1152/ajprenal.00204.2005

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