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Article

Diabetic kidney disease in FVB/NJ Akita mice: temporal pattern of kidney injury and urinary nephrin excretion.

PloS one - 1 Jan 2012

Chang Jae-Hyung, Paik Seung-Yeol, Mao Lan, Eisner William, Flannery Patrick J, Wang Liming, Tang Yuping, Mattocks Natalie, Hadjadj Samy, Goujon Jean-Michel, Ruiz Phillip, Gurley Susan B, Spurney Robert F

Abstract excerpt

Akita mice are a genetic model of type 1 diabetes. In the present studies, we investigated the phenotype of Akita mice on the FVB/NJ background and examined urinary nephrin excretion as a marker of kidney injury. Male Akita mice were compared with non-diabetic controls for functional and structural characteristics of renal and cardiac disease. Podocyte number and apoptosis as well as urinary nephrin excretion...

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Albuminuria
Diabetes Complications
Diabetes Mellitus, Experimental
Diabetic Nephropathies
Hyperglycemia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoenzyme Techniques

Mice, Inbred Strains

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Identifiers

PMID: 22496773
DOI: 10.1371/journal.pone.0033942
PMCID: PMC3319540

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