Article

Nephron filtration rate and proximal tubular fluid reabsorption in the Akita mouse model of type I diabetes mellitus

2013-03-11

Abstract excerpt

An increase of glomerular filtration rate (hyperfiltration) is an early functional change associated with type I or type II diabetes mellitus in patients and animal models. The causes underlying glomerular hyperfiltration are not entirely clear. There is evidence from studies in the streptozotocin model of diabetes in rats that an increase of proximal tubular reabsorption results in the withdrawal of a vasoconstri...

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Literature Corpus work: 65d4fbfe-4423-52f8-b950-7423ec7d3c97
DOI: 10.12688/f1000research.2-83.v1

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