Article
Receptor Reserve Moderates Mesolimbic Responses to Opioids in a Humanized Mouse Model of the OPRM1 A118G Polymorphism.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Oct 2015
Robinson J Elliott, Vardy Eyal, DiBerto Jeffrey F, Chefer Vladimir I, White Kate L, Fish Eric W, Chen Meng, Gigante Eduardo, Krouse Michael C, Sun Hui, Thorsell Annika, Roth Bryan L, Heilig Markus, Malanga C J
Abstract excerpt
The OPRM1 A118G polymorphism is the most widely studied μ-opioid receptor (MOR) variant. Although its involvement in acute alcohol effects is well characterized, less is known about the extent to which it alters responses to opioids. Prior work has shown that both electrophysiological and analgesic responses to morphine but not to fentanyl are moderated by OPRM1 A118G variation, but the mechanism behind this...
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