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Article

Reduced expression of the μ opioid receptor in some, but not all, brain regions in mice with OPRM1 A112G.

Neuroscience - 15 Mar 2012

Wang Y-J, Huang P, Ung A, Blendy J A, Liu-Chen L-Y

Abstract excerpt

OPRM1 A118G is a common single nucleotide polymorphism (SNP) in the coding region of the human mu opioid receptor (MOPR) gene OPRM1. This SNP is associated with higher morphine doses required for postoperative analgesia as well as a variety of drug addiction phenotypes. A mouse model possessing the equivalent substitution (A112G) in the Oprm1 gene was generated to facilitate mechanistic studies. Mice homozygous...

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Identifiers

PMID: 22240251
DOI: 10.1016/j.neuroscience.2011.12.033
PMCID: PMC3772531

Genes

OPRM1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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