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Article

Human Mu Opioid Receptor (OPRM1 A118G) polymorphism is associated with brain mu-opioid receptor binding potential in smokers.

Proceedings of the National Academy of Sciences of the United States of America - 31 May 2011

Ray Riju, Ruparel Kosha, Newberg Andrew, Wileyto E Paul, Loughead James W, Divgi Chaitanya, Blendy Julie A, Logan Jean, Zubieta Jon-Kar, Lerman Caryn

Abstract excerpt

Evidence points to the endogenous opioid system, and the mu-opioid receptor (MOR) in particular, in mediating the rewarding effects of drugs of abuse, including nicotine. A single nucleotide polymorphism (SNP) in the human MOR gene (OPRM1 A118G) has been shown to alter receptor protein level in preclinical models and smoking behavior in humans. To clarify the underlying mechanisms for these associations, we...

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Identifiers

PMID: 21576462
DOI: 10.1073/pnas.1018699108
PMCID: PMC3107291

Genes

OPRM1

Variants

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Human Mu Opioid Receptor (OPRM1 A118G) polymorphism is associated with brain mu-opioid receptor binding potential in smokers.PMID 21576462Read ↗

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