Article
The OPRM1 A118G polymorphism: converging evidence against associations with alcohol sensitivity and consumption.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jun 2018
Sloan M E, Klepp T D, Gowin J L, Swan J E, Sun H, Stangl B L, Ramchandani V A
Abstract excerpt
The endogenous opioid system may be involved in the development and maintenance of alcohol use disorder (AUD) and is a target for existing AUD pharmacotherapies. A functional polymorphism of the mu-opioid receptor gene (OPRM1 A118G, rs1799971) may alter the risk of developing AUD. Human laboratory studies have demonstrated that minor allele carriers self-administer more alcohol, show greater sensitivity to...
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