Article
Pharmacological consequence of the A118G μ opioid receptor polymorphism on morphine- and fentanyl-mediated modulation of Ca²⁺ channels in humanized mouse sensory neurons.
Anesthesiology - 1 Nov 2011
Mahmoud Saifeldin, Thorsell Annika, Sommer Wolfgang H, Heilig Markus, Holgate Joan K, Bartlett Selena E, Ruiz-Velasco Victor
Abstract excerpt
BACKGROUND: The most common functional single nucleotide polymorphism of the human OPRM1 gene, A118G, has been shown to be associated with interindividual differences in opioid analgesic requirements, particularly with morphine, in patients with acute postoperative pain. The purpose of this study was to examine whether this polymorphism would modulate the morphine and fentanyl pharmacological profile of sensory...
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