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Article

Mouse model of OPRM1 (A118G) polymorphism has sex-specific effects on drug-mediated behavior.

Proceedings of the National Academy of Sciences of the United States of America - 30 Jun 2009

Mague Stephen D, Isiegas Carolina, Huang Peng, Liu-Chen Lee-Yuan, Lerman Caryn, Blendy Julie A

Abstract excerpt

A single nucleotide polymorphism (SNP) in the human mu-opioid receptor gene (OPRM1 A118G) has been widely studied for its association in a variety of drug addiction and pain sensitivity phenotypes; however, the extent of these adaptations and the mechanisms underlying these associations remain elusive. To clarify the functional mechanisms linking the OPRM1 A118G SNP to addiction and analgesia phenotypes, we...

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Source

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Identifiers

PMID: 19528658
DOI: 10.1073/pnas.0901800106
PMCID: PMC2705603

Genes

OPRM1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mouse model of OPRM1 (A118G) polymorphism has sex-specific effects on drug-mediated behavior.PMID 19528658Read ↗

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Genetic variation in the behavioral effects of buprenorphine in female mice derived from a murine model of the OPRM1 A118G polymorphism.Semantic proximity Read ↗

Reduced expression of the μ opioid receptor in some, but not all, brain regions in mice with OPRM1 A112G.Semantic proximity Read ↗

Oprm1 A112G, a single nucleotide polymorphism, alters expression of stress-responsive genes in multiple brain regions in male and female mice.Semantic proximity Read ↗

Mouse model of the OPRM1 (A118G) polymorphism: differential heroin self-administration behavior compared with wild-type mice.Semantic proximity Read ↗

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Increased ethanol drinking in "humanized" mice expressing the mu opioid receptor A118G polymorphism are mediated through sex-specific mechanisms.Semantic proximity Read ↗

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Relapse-like behavior in a mouse model of the OPRM1 (mu-opioid receptor) A118G polymorphism: Examination with intravenous oxycodone self-administration.Semantic proximity Read ↗

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