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Article

Influence of the OPRM1 A118G polymorphism on alcohol-induced euphoria, risk for alcoholism and the clinical efficacy of naltrexone.

Pharmacogenomics - 1 Jul 2012

Setiawan Elaine, Pihl Robert O, Benkelfat Chawki, Leyton Marco

Abstract excerpt

Alcohol-use disorders are thought to be heterogeneous in etiology, pathophysiology and response to treatment. One hypothesized contributor to this variability is the common A118G polymorphism of the µ-opioid receptor gene, OPRM1. This article critically evaluates the evidence that the A118G substitution affects subjective, behavioral and neurobiological responses to alcohol and the opioid receptor antagonist,...

Topics

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Alcoholism
Alcohols
Genotype
Naltrexone
Narcotic Antagonists

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pharmacogenetics

Polymorphism, Single Nucleotide

Receptors, Opioid, mu

Source

Identifiers

PMID: 22909206
DOI: 10.2217/pgs.12.99

Genes

OPRM1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Influence of the OPRM1 A118G polymorphism on alcohol-induced euphoria, risk for alcoholism and the clinical efficacy of naltrexone.PMID 22909206Read ↗

A polymorphism of the mu-opioid receptor gene (OPRM1) and sensitivity to the effects of alcohol in humans.Semantic proximity Read ↗

The μ-opioid receptor and treatment response to naltrexone.Semantic proximity Read ↗

The OPRM1 A118G polymorphism: converging evidence against associations with alcohol sensitivity and consumption.Semantic proximity Read ↗

Association of µ-opioid receptor (OPRM1) gene polymorphism with response to naltrexone in alcohol dependence: a systematic review and meta-analysis.Semantic proximity Read ↗

The role of OPRM1 polymorphism in the etiology of alcoholism.Semantic proximity Read ↗

OPRM1 A118G genotype fails to predict the effectiveness of naltrexone treatment for alcohol dependence.Semantic proximity Read ↗

Possible association between OPRM1 genetic variance at the 118 locus and alcohol dependence in a large treatment sample: relationship to alcohol dependence symptoms.Semantic proximity Read ↗

Effects of naltrexone on alcohol sensitivity and genetic moderators of medication response: a double-blind placebo-controlled study.Semantic proximity Read ↗

Opioid Antagonists and the A118G Polymorphism in the μ-Opioid Receptor Gene: Effects of GSK1521498 and Naltrexone in Healthy Drinkers Stratified by OPRM1 Genotype.Semantic proximity Read ↗

Increased attributable risk related to a functional mu-opioid receptor gene polymorphism in association with alcohol dependence in central Sweden.Semantic proximity Read ↗

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