Article
A genetic determinant of the striatal dopamine response to alcohol in men.
Molecular psychiatry - 1 Aug 2011
Ramchandani V A, Umhau J, Pavon F J, Ruiz-Velasco V, Margas W, Sun H, Damadzic R, Eskay R, Schoor M, Thorsell A, Schwandt M L, Sommer W H, George D T, Parsons L H, Herscovitch P, Hommer D, Heilig M
Abstract excerpt
Excessive alcohol use, a major cause of morbidity and mortality, is less well understood than other addictive disorders. Dopamine release in ventral striatum is a common element of drug reward, but alcohol has an unusually complex pharmacology, and humans vary greatly in their alcohol responses. This variation is related to genetic susceptibility for alcoholism, which contributes more than half of alcoholism...
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