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Article

OPRM1 SNP (A118G): involvement in disease development, treatment response, and animal models.

Drug and alcohol dependence - 1 May 2010

Mague Stephen D, Blendy Julie A

Abstract excerpt

Endogenous opioids acting at mu-opioid receptors mediate many biological functions. Pharmacological intervention at these receptors has greatly aided in the treatment of acute and chronic pain, in addition to other uses. However, the development of tolerance and dependence has made it difficult t...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

Share to Receptors, Opioid, mu

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Source

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Identifiers

PMID: 20074870
DOI: 10.1016/j.drugalcdep.2009.12.016
PMCID: PMC2887703

Genes

OPRM1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20074870-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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OPRM1 SNP (A118G): involvement in disease development, treatment response, and animal models.PMID 20074870Read ↗

Mouse model of OPRM1 (A118G) polymorphism has sex-specific effects on drug-mediated behavior.Semantic proximity Read ↗

Genetic variation in the behavioral effects of buprenorphine in female mice derived from a murine model of the OPRM1 A118G polymorphism.Semantic proximity Read ↗

The OPRM1 A118G Polymorphism Revisited: Recent Developments and Implications for Personalized Treatment.Semantic proximity Read ↗

Reduced expression of the μ opioid receptor in some, but not all, brain regions in mice with OPRM1 A112G.Semantic proximity Read ↗

Overview of genetic analysis of human opioid receptors.Semantic proximity Read ↗

Overview of Genetic Analysis of Human Opioid Receptors.Semantic proximity Read ↗

Pharmacogenomics of the human µ-opioid receptor.Semantic proximity Read ↗

Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction.Semantic proximity Read ↗

Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G.Semantic proximity Read ↗

Consequences of the 118A&gt;G polymorphism in the OPRM1 gene: translation from bench to bedside?Semantic proximity Read ↗

Mouse model of OPRM1 (A118G) polymorphism has altered hippocampal function.Semantic proximity Read ↗

Oprm1 A112G, a single nucleotide polymorphism, alters expression of stress-responsive genes in multiple brain regions in male and female mice.Semantic proximity Read ↗

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