Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Morphine-induced antinociception and reward in "humanized" mice expressing the mu opioid receptor A118G polymorphism.

Brain research bulletin - 1 May 2016

Henderson-Redmond Angela N, Yuill Matthew B, Lowe Tammy E, Kline Aaron M, Zee Michael L, Guindon Josée, Morgan Daniel J

Abstract excerpt

The rewarding and antinociceptive effects of opioids are mediated through the mu-opioid receptor. The A118G single nucleotide polymorphism in this receptor has been implicated in drug addiction and differences in pain response. Clinical and preclinical studies have found that the G allele is associated with increased heroin reward and self-administration, elevated post-operative pain, and reduced analgesic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Analgesics
Share to Analgesics, Opioid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Tolerance

Share to Mice, Transgenic

Share to Morphine

Share to Pain Measurement

Share to Receptors, Opioid, mu

Source

Open in PubMed Open full text

Identifiers

PMID: 26521067
DOI: 10.1016/j.brainresbull.2015.10.007
PMCID: PMC4848164

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Morphine-induced antinociception and reward in "humanized" mice expressing the mu opioid receptor A118G polymorphism.PMID 26521067Read ↗

Increased ethanol drinking in "humanized" mice expressing the mu opioid receptor A118G polymorphism are mediated through sex-specific mechanisms.Semantic proximity Read ↗

Receptor Reserve Moderates Mesolimbic Responses to Opioids in a Humanized Mouse Model of the OPRM1 A118G Polymorphism.Semantic proximity Read ↗

Genetic variation in the behavioral effects of buprenorphine in female mice derived from a murine model of the OPRM1 A118G polymorphism.Semantic proximity Read ↗

Mouse model of OPRM1 (A118G) polymorphism has sex-specific effects on drug-mediated behavior.Semantic proximity Read ↗

Pharmacological consequence of the A118G μ opioid receptor polymorphism on morphine- and fentanyl-mediated modulation of Ca²⁺ channels in humanized mouse sensory neurons.Semantic proximity Read ↗

OPRM1 SNP (A118G): involvement in disease development, treatment response, and animal models.Semantic proximity Read ↗

Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction.Semantic proximity Read ↗

Reduced expression of the μ opioid receptor in some, but not all, brain regions in mice with OPRM1 A112G.Semantic proximity Read ↗

Cocaine-induced suppression of saccharin intake and morphine modulation of Ca²⁺ channel currents in sensory neurons of OPRM1 A118G mice.Semantic proximity Read ↗

Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G.Semantic proximity Read ↗

The μ-opioid receptor gene polymorphism 118A>G weakens the pharmacological action of buprenorphine.Semantic proximity Read ↗

Heroin-induced suppression of saccharin intake in OPRM1 A118G mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.