Genome-destabilizing effects associated with top1 loss or accumulation of top1 cleavage complexes in yeast.

doi:10.1371/journal.pgen.1005098

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Article

Genome-destabilizing effects associated with top1 loss or accumulation of top1 cleavage complexes in yeast.

PLoS genetics - 1 Apr 2015

Andersen Sabrina L, Sloan Roketa S, Petes Thomas D, Jinks-Robertson Sue

Abstract excerpt

Topoisomerase 1 (Top1), a Type IB topoisomerase, functions to relieve transcription- and replication-associated torsional stress in DNA. We investigated the effects of Top1 on genome stability in Saccharomyces cerevisiae using two different assays. First, a sectoring assay that detects loss of heterozygosity (LOH) on a specific chromosome was used to measure reciprocal crossover (RCO) rates. Features of...

Topics

Camptothecin
Crossing Over, Genetic
DNA Topoisomerases, Type I
Genome, Fungal
Genomic Instability
Mutation
RNA, Ribosomal
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Topoisomerase I Inhibitors

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Identifiers

PMID: 25830313
DOI: 10.1371/journal.pgen.1005098
PMCID: PMC4382028

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