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Article

Role for topoisomerase 1 in transcription-associated mutagenesis in yeast.

Proceedings of the National Academy of Sciences of the United States of America - 11 Jan 2011

Lippert Malcolm J, Kim Nayun, Cho Jang-Eun, Larson Ryan P, Schoenly Nathan E, O'Shea Shannon H, Jinks-Robertson Sue

Abstract excerpt

High levels of transcription in Saccharomyces cerevisiae are associated with increased genetic instability, which has been linked to DNA damage. Here, we describe a pGAL-CAN1 forward mutation assay for studying transcription-associated mutagenesis (TAM) in yeast. In a wild-type background with no...

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Identifiers

PMID: 21177427
DOI: 10.1073/pnas.1012363108
PMCID: PMC3021083

Genes

TOP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21177427-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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