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Article

Fork-barrier-independent roles of topoisomerase I in the ribosomal DNA.

Genetics - 4 Jun 2025

Molinar Temistocles, Sultanov Daniel, Klein Hannah, Hochwagen Andreas

Abstract excerpt

Topoisomerase I, a nickase that allows swiveling of the DNA substrate, is highly enriched in the ribosomal DNA (rDNA) from yeast to humans, but its function at this locus remains poorly understood. S. cerevisiae mutants lacking topoisomerase I (top1) exhibit pronounced rDNA instability and accumulate bubbles of single-stranded DNA (ssDNA) on 35S ribosomal RNA genes, suggesting a role in relieving...

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Identifiers

PMID: 40119707
DOI: 10.1093/genetics/iyaf052
PMCID: PMC12135192

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