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Article

Topoisomerase 1 provokes the formation of short deletions in repeated sequences upon high transcription in Saccharomyces cerevisiae.

Proceedings of the National Academy of Sciences of the United States of America - 11 Jan 2011

Takahashi Diane T, Burguiere-Slezak Guenaelle, Van der Kemp Patricia Auffret, Boiteux Serge

Abstract excerpt

High transcription is associated with genetic instability, notably increased spontaneous mutation rates, which is a phenomenon termed Transcription-Associated-Mutagenesis (TAM). In this study, we investigated TAM using the chromosomal CAN1 gene under the transcriptional control of two strong and inducible promoters (pGAL1 and pTET) in Saccharomyces cerevisiae. Both pTET- and pGAL1-driven high transcription at the...

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Share to Amino Acid Transport Systems, Basic
Share to DNA Topoisomerases, Type I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Deletion

Share to Gene Expression Regulation, Fungal

Share to Mutagenesis

Share to Reverse Transcriptase Polymerase Chain Reaction

Share to Saccharomyces cerevisiae Proteins

Share to Sequence Deletion

Source

Open in PubMed Open full text

Identifiers

PMID: 21177431
DOI: 10.1073/pnas.1012582108
PMCID: PMC3021075

Genes

MUS81
RAD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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