Article
Global transcription regulation by DNA topoisomerase I in exponentially growing Saccharomyces cerevisiae cells: activation of telomere-proximal genes by TOP1 deletion.
Journal of molecular biology - 21 Mar 2008
Lotito Luca, Russo Alessandra, Chillemi Giovanni, Bueno Susana, Cavalieri Duccio, Capranico Giovanni
Abstract excerpt
To establish the cellular functions of DNA topoisomerase I-B (Top1p) at a global level, we have determined the expression profiles and histone modification patterns affected by TOP1 gene deletion (DeltaTOP1) in Saccharomyces cerevisiae. In exponentially growing cells, DeltaTOP1 specifically increases transcription of telomere-proximal genes and decreases glucose utilization and energy production pathways....
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