A novel mutation in DNA topoisomerase I of yeast causes DNA damage and RAD9-dependent cell cycle arrest.

doi:10.1093/genetics/133.4.799

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Article

A novel mutation in DNA topoisomerase I of yeast causes DNA damage and RAD9-dependent cell cycle arrest.

Genetics - 1 Apr 1993

Levin N A, Bjornsti M A, Fink G R

Abstract excerpt

DNA topoisomerases, enzymes that alter the superhelicity of DNA, have been implicated in such critical cellular functions as transcription, DNA replication, and recombination. In the yeast Saccharomyces cerevisiae, a null mutation in the gene encoding topoisomerase I (TOP1) causes elevated levels...

Topics

Alleles
Arginine
Camptothecin
Cell Cycle
Cell Cycle Proteins
DNA Damage
DNA Repair
DNA Topoisomerases, Type I
DNA, Ribosomal
Fungal Proteins
Lysine
Mutation
Recombination, Genetic
Saccharomyces cerevisiae

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