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Quantitative changes in Gimap3 and Gimap5 expression modify mitochondrial DNA segregation in mice.

Genetics - 1 May 2015

Jokinen Riikka, Lahtinen Taina, Marttinen Paula, Myöhänen Maarit, Ruotsalainen Pilvi, Yeung Nicolas, Shvetsova Antonina, Kastaniotis Alexander J, Hiltunen J Kalervo, Öhman Tiina, Nyman Tuula A, Weiler Hartmut, Battersby Brendan J

Abstract excerpt

Mammalian mitochondrial DNA (mtDNA) is a high-copy maternally inherited genome essential for aerobic energy metabolism. Mutations in mtDNA can lead to heteroplasmy, the co-occurence of two different mtDNA variants in the same cell, which can segregate in a tissue-specific manner affecting the onset and severity of mitochondrial dysfunction. To investigate mechanisms regulating mtDNA segregation we use a...

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Identifiers

PMID: 25808953
DOI: 10.1534/genetics.115.175596
PMCID: PMC4423365

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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