Article
Zinc finger protein Zfp335 is required for the formation of the naïve T cell compartment.
eLife - 24 Oct 2014
Han Brenda Y, Wu Shuang, Foo Chuan-Sheng, Horton Robert M, Jenne Craig N, Watson Susan R, Whittle Belinda, Goodnow Chris C, Cyster Jason G
Abstract excerpt
The generation of naïve T lymphocytes is critical for immune function yet the mechanisms governing their maturation remain incompletely understood. We have identified a mouse mutant, bloto, that harbors a hypomorphic mutation in the zinc finger protein Zfp335. Zfp335(bloto/bloto) mice exhibit a naïve T cell deficiency due to an intrinsic developmental defect that begins to manifest in the thymus and continues...
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