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Essential role of MFSD1-GLMP-GIMAP5 in lymphocyte survival and liver homeostasis

6 Dec 2023

Abstract excerpt

We detected ENU-induced alleles of Mfsd1 (encoding the major facilitator superfamily domain containing 1 protein) that caused lymphopenia, splenomegaly, progressive liver pathology, and extramedullary hematopoiesis (EMH). MFSD1 is a lysosomal membrane-bound solute carrier protein with no previously described function in immunity. By proteomic analysis, we identified association between MFSD1 and both GLMP...

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PMID: 38055739
DOI: 10.1073/pnas.2314429120

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