Article
Mitochondrial genetics cooperate with nuclear genetics to selectively alter immune cell development/trafficking.
Biochimica et biophysica acta. Molecular basis of disease - 1 May 2020
Beadnell T C, Fain C, Vivian C J, King J C G, Hastings R, Markiewicz M A, Welch D R
Abstract excerpt
The nuclear genome drives differences in immune cell populations and differentiation potentials, in part regulated by changes in metabolism. Despite this connection, the role of mitochondrial DNA (mtDNA) polymorphisms (SNP) in this process has not been examined. Using mitochondrial nuclear exchange (MNX) mice, we and others have shown that mtDNA strongly influences varying aspects of cell biology and disease....
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