Agm1/Pgm3-mediated sugar nucleotide synthesis is essential for hematopoiesis and development.

doi:10.1128/MCB.00802-07

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Article

Agm1/Pgm3-mediated sugar nucleotide synthesis is essential for hematopoiesis and development.

Molecular and cellular biology - 1 Aug 2007

Greig Kylie T, Antonchuk Jennifer, Metcalf Donald, Morgan Phillip O, Krebs Danielle L, Zhang Jian-Guo, Hacking Douglas F, Bode Lars, Robb Lorraine, Kranz Christian, de Graaf Carolyn, Bahlo Melanie, Nicola Nicos A, Nutt Stephen L, Freeze Hudson H, Alexander Warren S, Hilton Douglas J, Kile Benjamin T

Abstract excerpt

Carbohydrate modification of proteins includes N-linked and O-linked glycosylation, proteoglycan formation, glycosylphosphatidylinositol anchor synthesis, and O-GlcNAc modification. Each of these modifications requires the sugar nucleotide UDP-GlcNAc, which is produced via the hexosamine biosynthesis pathway. A key step in this pathway is the interconversion of GlcNAc-6-phosphate (GlcNAc-6-P) and GlcNAc-1-P,...

Topics

Alleles
Animals
Base Sequence
Embryonic Development
Female
Glycosylation
Hematopoiesis
Male
Mice
Mice, Inbred BALB C

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred C57BL

Molecular Sequence Data

Mutation

Pancreas

Phosphoglucomutase

RNA Splicing

Salivary Glands

Spermatogenesis

Source

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Identifiers

PMID: 17548465
DOI: 10.1128/MCB.00802-07
PMCID: PMC1952135

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