Article
Two reciprocal translocations provide new clues to the high mutability of the Grid2 locus.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jan 2005
Robinson Kellie O, Petersen Angela M, Morrison Stephanie N, Elso Colleen M, Stubbs Lisa
Abstract excerpt
We describe two new mutations, 153Gso and 154Gso, associated with reciprocal translocations with a common breakpoint in mouse chromosome 6B3 (Mmu6B3). The translocations arose independently in offspring of male mice treated with chlorambucil and glycidamide, respectively. Homozygotes of both mutant stocks display a characteristic gait ataxia with 'foot-patting' behavior; despite their ataxia the mutant animals...
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