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Article

Nuclear genetic control of mitochondrial DNA segregation.

Nature genetics - 1 Feb 2003

Battersby Brendan J, Loredo-Osti J C, Shoubridge Eric A

Abstract excerpt

Mammalian mitochondrial DNA (mtDNA) is a high copy-number, maternally inherited genome that codes for a small number of essential proteins involved in oxidative phosphorylation. Mutations in mtDNA are responsible for a broad spectrum of clinical disorders. The segregation pattern of pathogenic mtDNA mutants is an important determinant of the nature and severity of mitochondrial disease, but it varies with the...

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PMID: 12539044
DOI: 10.1038/ng1073

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