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Article

Quantitative trait loci mapping provides insights into the genetic regulation of dendritic cell numbers in mouse tissues.

Cell reports - 25 Jun 2024

Oliveira Thiago Y, Merkenschlager Julia, Eisenreich Thomas, Bortolatto Juliana, Yao Kai-Hui, Gatti Daniel M, Churchill Gary A, Nussenzweig Michel C, Breton Gaëlle

Abstract excerpt

To explore the influence of genetics on homeostatic regulation of dendritic cell (DC) numbers, we present a screen of DCs and their progenitors in lymphoid and non-lymphoid tissues in Collaborative Cross (CC) and Diversity Outbred (DO) mice. We report 30 and 71 loci with logarithm of the odds (LOD) scores >8.18 and ranging from 6.67 to 8.19, respectively. The analysis reveals the highly polygenic and pleiotropic...

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Source

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Identifiers

PMID: 38823019
DOI: 10.1016/j.celrep.2024.114296
PMCID: PMC11726347

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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