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Article

Histone tails regulate DNA methylation by allosterically activating de novo methyltransferase.

Cell research - 1 Aug 2011

Li Bin-Zhong, Huang Zheng, Cui Qing-Yan, Song Xue-Hui, Du Lin, Jeltsch Albert, Chen Ping, Li Guohong, Li En, Xu Guo-Liang

Abstract excerpt

Cytosine methylation of genomic DNA controls gene expression and maintains genome stability. How a specific DNA sequence is targeted for methylation by a methyltransferase is largely unknown. Here, we show that histone H3 tails lacking lysine 4 (K4) methylation function as an allosteric activator for methyltransferase Dnmt3a by binding to its plant homeodomain (PHD). In vitro, histone H3 peptides stimulated the...

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Identifiers

PMID: 21606950
DOI: 10.1038/cr.2011.92
PMCID: PMC3193484

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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