Article
THAP9 transposase cleaves DNA via conserved acidic residues in an RNaseH-like domain
2020-10-06
Abstract excerpt
The catalytic domain of most ‘cut and paste’ DNA transposases have the canonical RNase-H fold which is also shared by other polynucleotidyl transferases like retroviral integrases and the RAG1 subunit of V(D)J recombinase. The RNase-H fold is a mixture of beta sheets and alpha helices with three acidic residues (Asp, Asp, Glu/Asp - DDE/D) that are involved in metal-mediated cleavage and subsequent integration of D...
Topics
Open a Topic to create a Post that cites this publication.
Identifiers and source
- Literature Corpus work
- 74c1cd03-16e8-5797-ad04-adf0d7c0c029
- DOI
- 10.1101/2020.10.06.328898