Article
Evolutionary adaptation of the fly Pygo PHD finger toward recognizing histone H3 tail methylated at arginine 2.
Structure (London, England : 1993) - 3 Dec 2013
Miller Thomas C R, Mieszczanek Juliusz, Sánchez-Barrena María José, Rutherford Trevor J, Fiedler Marc, Bienz Mariann
Abstract excerpt
Pygo proteins promote Armadillo- and β-catenin-dependent transcription, by relieving Groucho-dependent repression of Wnt targets. Their PHD fingers bind histone H3 tail methylated at lysine 4, and to the HD1 domain of their Legless/BCL9 cofactors, linking Pygo to Armadillo/β-catenin. Intriguingly, fly Pygo orthologs exhibit a tryptophan > phenylalanine substitution in their histone pocket-divider which reduces...
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