Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of mutants in bHLH region on structure stability and protein-DNA binding energy in DECs.

Journal of biomolecular structure & dynamics - 1 Jul 2017

Kong Yi, Wang Zhen, Jia Yanfei, Li Ping, Hao Shuhua, Wang Yunshan

Abstract excerpt

The human DEC subfamily contains two highly conserved members belonging to basic helix-loop-helix (bHLH) transcription factors. This conserved family is spread widely among various species with the function of regulating various crucial molecular signaling pathways. Due to the significance of DECs for important biological processes, their relationship with diseases and the lack of experimentally proven...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Basic Helix-Loop-Helix Transcription Factors
Share to Dimerization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA-Binding Proteins

Share to Molecular Dynamics Simulation

Share to Mutation

Share to Promoter Regions, Genetic

Share to Signal Transduction

Source

Identifiers

PMID: 27499354
DOI: 10.1080/07391102.2016.1196463

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of mutants in bHLH region on structure stability and protein-DNA binding energy in DECs.PMID 27499354Read ↗

Mechanistic insight of DACH1 receptor in the development of carcinoma insurgence through MD simulation studies.Semantic proximity Read ↗

Structural basis for the HMGCR interaction with UBIAD1 mutants causing Schnyder corneal dystrophySemantic proximity Read ↗

Structural insight, mutation and interactions in human Beta-catenin and SOX17 protein: A molecular-level outlook for organogenesis.Semantic proximity Read ↗

Computational modeling of the bHLH domain of the transcription factor TWIST1 and R118C, S144R and K145E mutants.Semantic proximity Read ↗

Phosphorylation Regulation on the Homo-Dimeric Binding of Transactive Response DNA-Binding Protein.Semantic proximity Read ↗

Discovery of a hidden transient state in all bromodomain familiesSemantic proximity Read ↗

Deadenylation and Decapping Factors Cooperatively Stimulate Biochemical Activities of DEAD-Box ATPase Dhh1Semantic proximity Read ↗

Kinetic, thermodynamic, and structural characterizations of the association between Nrf2-DLGex degron and Keap1.Semantic proximity Read ↗

Investigating the Influence of Hotspot Mutations in Protein-Protein Interaction of IDH1 Homodimer Protein: A Computational Approach.Semantic proximity Read ↗

Folding perspectives of an intrinsically disordered transactivation domain and its single mutation breaking the folding propensity.Semantic proximity Read ↗

A Study on the Binding Mechanism and the Impact of Key Residue Mutations between SND1 and MTDH Peptide through Molecular Dynamics Simulations.Semantic proximity Read ↗

Investigation of the β-sheet interactions between dHP1 chromodomain and histone 3.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.