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Article

Structural basis of molecular recognition of helical histone H3 tail by PHD finger domains.

The Biochemical journal - 4 May 2017

Bortoluzzi Alessio, Amato Anastasia, Lucas Xavier, Blank Manuel, Ciulli Alessio

Abstract excerpt

The plant homeodomain (PHD) fingers are among the largest family of epigenetic domains, first characterized as readers of methylated H3K4. Readout of histone post-translational modifications by PHDs has been the subject of intense investigation; however, less is known about the recognition of secondary structure features within the histone tail itself. We solved the crystal structure of the PHD finger of the...

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Identifiers

PMID: 28341809
DOI: 10.1042/BCJ20161053
PMCID: PMC5415848

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