Article
The role of intercalating residues in chromosomal high-mobility-group protein DNA binding, bending and specificity.
Nucleic acids research - 1 Jun 2003
Klass Janet, Murphy Frank V, Fouts Susan, Serenil Melissa, Changela Anita, Siple Jessica, Churchill Mair E A
Abstract excerpt
Ubiquitous high-mobility-group (HMGB) chromosomal proteins bind DNA in a non-sequence- specific fashion to promote chromatin function and gene regulation. Minor groove DNA binding of the HMG domain induces substantial DNA bending toward the major groove, and several interfacial residues contribute by DNA intercalation. The role of the intercalating residues in DNA binding, bending and specificity was...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.